How much is a ticket from Panama City to Santiago de Cuba?

Depending on when you travel and how far in advance you book, fares between Panama City and Santiago de Cuba can differ a lot.

Choose a date to explore the best fares now.

If you’re flexible with timing, consider overnight flights — they often cost less and are less crowded. Exploring multiple date and time combinations can help you find the cheapest solution.

Which departure and arrival airports are available?

Between Panama City and Santiago de Cuba, flight options may depend on the combination of airports available.

• Airports in Panama City: Panama City is connected by 2 airports - Pacífico International Airport, Paitilla.
• Airports in Santiago de Cuba: Santiago de Cuba is the only active airport in the area.

Sometimes flying into a nearby city can be more cost-effective. When a city has multiple airports, it’s worth comparing different flight combinations.

Choose the right flight for your trip from Panama City to Santiago de Cuba

Jetcost helps you tailor your flight search based on what matters to you — flight length, budget, airline, or agency. Whether you prefer round-trip or one-way, direct or with stopovers, you’ll see options from eDreams, Expedia, and more.

Other popular destinations

Flying to Cuba? Many users also explore: Camaguey, Havana, Holguin, Santa Clara, Santiago de Cuba.

Looking for a specific airline? Select it directly in the filters to speed up your search. The search filters help you see only the options that match your needs.